A nested case-control study in studying the relationship between interleukin-6, endothelin-1,E-selectin and the risk of cardio-cerebrovascular events.

Qiuyan Chen; Xiaoqing BU; Yan Liu; Juan XU; Fanlong Kong; Guiyan Wang; Yonghong Zhang

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A nested case-control study in studying the relationship between interleukin-6, endothelin-1,E-selectin and the risk of cardio-cerebrovascular events.

Author: Qiuyan CHEN ¹ ; Xiaoqing BU ¹ ; Yan LIU ¹ ; Juan XU ¹ ; Fanlong KONG ¹ ; Guiyan WANG ² ; Yonghong ZHANG ³
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1. Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China.
2. Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China
3. Department of Epidemiology, School of Public Health, Medical College of Soochow University, Suzhou, 215123, China. Email: yhzhang@suda.edu.cn.
Publication Type:Journal Article
MeSH: Cardiovascular Diseases; epidemiology; Case-Control Studies; Cerebrovascular Disorders; epidemiology; China; epidemiology; Cohort Studies; E-Selectin; blood; Endothelin-1; blood; Humans; Interleukin-6; blood; Odds Ratio; Risk
From: Chinese Journal of Epidemiology 2014;35(10):1151-1154
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the relationship between interleukin-6 (IL-6), endothelin-1 (ET-1), E-selectin and the risk of cardio-cerebrovascular events.
METHODSBased on a cohort study in which 2 589 Mongolians had been followed up for 10 years, a nested case-control study was carried out to analyze the relationship between IL-6, ET-1, E-selectin and the risk of cardio-cerebrovascular events. Logistic regression analysis was used to calculate the odds ratio (OR) and 95% confidence intervals (95%CI).
RESULTSThe average level of IL-6 (7.66 vs. 8.77 pg/ml), ET-1 (0.74 vs. 0.75 pg/ml) and E-selectin (17.96 vs. 18.32 ng/ml)were not significantly different between the case and the control groups (P > 0.05). Data from the logistic regression analysis showed that IL-6, ET-1 and E-selectin were not significantly associated with the risk of cardio-cerebrovascular events. The multivariable adjusted ORs (95%CI) on the risk of cardio-cerebrovascular events were 0.69 (0.41-1.16), 1.10 (0.66-1.85) and 1.19 (0.71-2.00) for the participants with IL-6>23.91 pg/ml, ET-1>1.33 pg/ml and E-selectin>24.43 ng/ml, respectively, compared with those having IL-6≤23.91 pg/ml, ET-1≤1.33 pg/ml or E-selectin≤24.43 ng/ml.
CONCLUSIONData from our study indicated that the levels of IL-6, ET-1 and E-selectin at baseline were not significantly associated with the risk of cardio-cerebrovascular events in people from Inner Mongolia.