Distribution of HIV-1 genotypes in China: a systematic review.
- Author:
Yingying SU
1
;
Huixin LIU
1
;
Jing WU
1
;
Lin ZHU
1
;
Ning WANG
2
Author Information
- Publication Type:Journal Article
- MeSH: China; epidemiology; Genotype; HIV Infections; epidemiology; virology; HIV-1; genetics; Humans
- From: Chinese Journal of Epidemiology 2014;35(10):1164-1168
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo provide information on the geographical distribution of HIV-1 genotypes and subtypes in the population of China.
METHODSA comprehensive search was carried out in China Hospital Knowledge Database (CHKD), Wanfang (Chinese), CBMDisc and PubMed databases to identify all studies published related to HIV-1 genotypes in China. All studies were grouped according to the sites, period and objects for analyzing the distribution of HIV genotypes.
RESULTSA total of 175 studies were included in this Meta-analysis, which contained 285 records. We found that the predominate genotypes in China were B' subtype, CRF01_AE, CRF07_BC and CRF08_BC, but the subtype distribution of HIV-1 was different in the western and southern parts of the country. CRF01_AE had a significant increase while subtype B' showed a decrease. There were various HIV-1 subtypes among individuals who acquired HIV through sexual contacts and CRF01_AE was most commonly identified in this group of people.
CONCLUSIONThe distribution of HIV-1 genotypes in Chinese people significantly changed, together with high complexity of the HIV-1 epidemics noticed in China.