Distribution of HIV-1 genotypes in China: a systematic review.

Yingying SU; Huixin Liu; Jing WU; Lin Zhu; Ning Wang

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Distribution of HIV-1 genotypes in China: a systematic review.

Author: Yingying SU ¹ ; Huixin LIU ¹ ; Jing WU ¹ ; Lin ZHU ¹ ; Ning WANG ²
Author Information

1. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China.
2. National Center for AIDS/STD Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206, China. Email: wangnbj@163.com.
Publication Type:Journal Article
MeSH: China; epidemiology; Genotype; HIV Infections; epidemiology; virology; HIV-1; genetics; Humans
From: Chinese Journal of Epidemiology 2014;35(10):1164-1168
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo provide information on the geographical distribution of HIV-1 genotypes and subtypes in the population of China.
METHODSA comprehensive search was carried out in China Hospital Knowledge Database (CHKD), Wanfang (Chinese), CBMDisc and PubMed databases to identify all studies published related to HIV-1 genotypes in China. All studies were grouped according to the sites, period and objects for analyzing the distribution of HIV genotypes.
RESULTSA total of 175 studies were included in this Meta-analysis, which contained 285 records. We found that the predominate genotypes in China were B' subtype, CRF01_AE, CRF07_BC and CRF08_BC, but the subtype distribution of HIV-1 was different in the western and southern parts of the country. CRF01_AE had a significant increase while subtype B' showed a decrease. There were various HIV-1 subtypes among individuals who acquired HIV through sexual contacts and CRF01_AE was most commonly identified in this group of people.
CONCLUSIONThe distribution of HIV-1 genotypes in Chinese people significantly changed, together with high complexity of the HIV-1 epidemics noticed in China.