Association between patatin-like phospholipase domain-containing protein 3 gene rs738409 polymorphism and non-alcoholic fatty liver disease susceptibility: a Meta-analysis
10.3760/cma.j.issn.0254-6450.2015.01.018
- VernacularTitle:Patatin样磷酯酶结构域蛋白3基因rs738409位点多态性与非酒精性脂肪肝易感性关系的Meta分析
- Author:
Pengbo WU
1
;
Yongxiang SHU
;
Fang GUO
;
Hesheng LUO
;
Guo ZHANG
;
Shiyun TAN
Author Information
1. 430060,武汉大学人民医院消化内科
- Keywords:
Non-alcoholic fatty liver;
Patatin-like phospholipase domain-containing protein 3;
Gene polymorphism;
Susceptibility;
Meta-analysis
- From:
Chinese Journal of Epidemiology
2015;36(1):78-82
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the association between patatin-like phospholipase domaincontaining protein 3 (PNPLA3) gene rs738409 polymorphism and the susceptibility of non-alcoholic fatty liver disease (NAFLD).Methods Data bases were comprehensively searched to retrace all the related studies on the association between PNPLA3 gene rs738409 polymorphism and susceptibility.Of NAFLD,the pooled OR with 95％ CI of the association between PNPLA3 gene rs738409 polymorphism and NAFLD susceptibility were performed using different genetic models.Subgroup analysis based on the source of population and sensitivity analysis was performed to detect the stability of results.Results 28 original studies with 6 216 patients and 8 218 controls were involved in the final combination of data.Findings from the meta-analyses showed that there were strong associations between PNPLA3 gene rs738409 polymorphism and the susceptibility of NAFLD,under different genetic model comparisons [GG vs.CC:OR=2.42,95％CI:1.83-3.21,P＜0.001 ;CG vs.CC:OR=1.28,95％CI:1.15-1.43,P＜0.001 ; CG+GG vs.CC:OR=1.31,95％CI:1.17-1.46,P＜ 0.001 ; GG vs.CC + GC:OR=2.26,95％CI:1.76-2.90,P＜0.001].Similar results were found in both Asian and Caucasian populations.Conclusion Results from the Meta-analysis strongly suggested that there appeared significant association between PNPLA3 gene rs738409 polymorphism and the susceptibility of NAFLD.
