Progress in research on TLR7 gene single nucleotide polymorphisms and copy number variations in autoimmune diseases.
10.3760/cma.j.issn.1003-9406.2017.02.029
- Author:
Jianxiong XI
1
;
Qiming ZHANG
;
Yanfeng ZOU
Author Information
1. Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, Hefei, Anhui 230032, China. zzyfl@163.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Autoimmune Diseases;
genetics;
DNA Copy Number Variations;
Genetic Predisposition to Disease;
Humans;
Polymorphism, Single Nucleotide;
Toll-Like Receptor 7;
genetics
- From:
Chinese Journal of Medical Genetics
2017;34(2):280-283
- CountryChina
- Language:Chinese
-
Abstract:
Autoimmune diseases (AID) are a group of complex disorders due to antibodies acting on self-antigens causing damage to the body. AID has long been considered as the outcome of genetic and environmental interactions. In recent years, studies have shown that increased susceptibility to AID may be associated with single nucleotide polymorphisms and copy number variations of Toll like receptor 7 (TLR7) gene, which provided a clue to further understanding of the pathogenesis of AID. This paper provides a review of the recent advances in understanding of the roles of TLR7 gene single nucleotide polymorphisms and copy number variations in AID.
