Analysis of clinical and genetic features of nine patients with disseminated superfacial actinic porokeratosis.
- Author:
Xiuling LI
1
;
Qian ZHOU
;
Lude ZHU
;
Zijun ZHAO
;
Peiru WANG
;
Linglin ZHANG
;
Guolong ZHANG
;
Xiuli WANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged, 80 and over; Case-Control Studies; Female; Humans; Male; Middle Aged; Mutation; genetics; Pedigree; Porokeratosis; genetics
- From: Chinese Journal of Medical Genetics 2017;34(4):481-485
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the clinical and genetic features of 9 ethnic Han Chinese patients with disseminated superfacial actinic porokeratosis (DSAP).
METHODSGenomic DNA was extracted from peripheral blood samples collected from the patients. PCR and direct sequencing were carried out for five patients from a family, 4 sporadic cases, and 120 healthy controls to identify potential mutations of four genes (MVK, MVD, PMVK, FDPS) involved in the mevalonate pathway as well as SLC17A9, SSH1, and SART3 genes. Pathogenecity of suspected mutations were assessed with SIFT, and Polyphen-2 scores.
RESULTSA c.746T>C mutation was identified in the family and two sporadic cases, while a c.875A>G mutation was identified in another sporadic case. No mutation was identified in the remainder genes among all patients. Scoring has suggested that the c.746T>C and c.875A>G mutations of the MVD gene are probably pathogenic.
CONCLUSIONc.746 T>C and c.875A>G of the MVD gene are most common mutations. Skin rashes of the patients have a strong connection with the sunlight, albeit a significant difference among patients was discovered.
