Association of Val66Met polymorphism of brain-derived neurotrophic factor gene with cognitive impairment and clinical symptoms in first episode schizophrenia.
- Author:
Chengcheng ZHANG
1
;
Xiaochu GU
;
Qiang WANG
;
Mingli LI
;
Wei DENG
;
Wanjun GUO
;
Liansheng ZHAO
;
Xiaohong MA
;
Tao LI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Brain-Derived Neurotrophic Factor; genetics; Case-Control Studies; Cognitive Dysfunction; genetics; Female; Genetic Predisposition to Disease; genetics; Humans; Male; Middle Aged; Polymorphism, Genetic; genetics; Schizophrenia; genetics; Young Adult
- From: Chinese Journal of Medical Genetics 2017;34(4):592-596
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the association of cognitive impairment and clinical symptoms in first-episode schizophrenia with the Val66Met (rs6265) polymorphism of brain-derived neurotrophic factor (BDNF) gene.
METHODSFor 87 patients with first-episode schizophrenia and 76 healthy controls, the Val66Met polymorphism was determined with a Taqman Assay-on-Demand method. Wechsler intelligence test was carried out for all participants. Correlation of cognitive impairment with clinical severity was also analyzed.
RESULTSThe patients were significantly lower in total IQ, verbal IQ and performance IQ compared to the controls. The lower total IQ (F=4.59, P= 0.01) and verbal IQ (F=4.44, P=0.01) were influenced by genetic factors and diagnostic interaction. The vertal IQ of Val/Val patients was significantly lower than those of Val/Met and Met/Met carriers. For the control group, the verbal IQ of Met/Met carriers was lower than that of Val/Met carriers, and the total IQ of Met/Met carriers was lower than those of Val/Met and Val/Val carriers. For the patient group, the total IQ of Val/Val carriers was negatively correlated with positive symptoms (r=-0.65, P=0.03) and thought disorders (r=-0.61, P=0.02).
CONCLUSIONCognitive impairment in first-episode schizophrenic patients is associated with the Val66Met polymorphism of the BDNF gene, and has an important clinical relevance.
