Glucose-6-phosphate-dehydrogenase deficiency and its correlation with other risk factors in jaundiced newborns in Southern Brazil.
- Author:
Clarissa Gutiérrez CARVALHO
1
;
Simone Martins CASTRO
;
Ana Paula SANTIN
;
Carina ZALESKI
;
Felipe Gutiérrez CARVALHO
;
Roberto GIUGLIANI
Author Information
- Publication Type:Journal Article
- Keywords: Glucosephosphate dehydrogenase; Hemoglobin; Hyperbilirubinemia; Jaundice; Neonatal
- MeSH: Brazil; epidemiology; Case-Control Studies; Female; Glucosephosphate Dehydrogenase; genetics; metabolism; Glucosephosphate Dehydrogenase Deficiency; complications; enzymology; genetics; Humans; Infant, Newborn; Jaundice, Neonatal; enzymology; epidemiology; etiology; genetics; Male; Mutation; Prospective Studies; Risk Factors
- From:Asian Pacific Journal of Tropical Biomedicine 2011;1(2):110-113
- CountryChina
- Language:English
-
Abstract:
OBJECTIVETo evaluate the correlation between glucose-6-phosphate-dehydrogenase (G6PD) deficiency and neonatal jaundice.
METHODSProspective, observational case-control study was conducted on 490 newborns admitted to Hospital de Clínicas de Porto Alegre for phototherapy, who all experienced 35 or more weeks of gestation, from March to December 2007. Enzymatic screening of G6PD activity was performed, followed by PCR.
RESULTSThere was prevalence of 4.6% and a boy-girl ratio of 3:1 in jaundiced newborns. No jaundiced neonate with ABO incompatibility presented G6PD deficiency, and no Mediterranean mutation was found. A higher proportion of deficiency was observed in Afro-descendants. There was no association with UGT1A1 variants.
CONCLUSIONSG6PD deficiency is not related to severe hyperbilirubinemia and considering the high miscegenation in this area of Brazil, other gene interactions should be investigated.
