Investigation of viral pathogens contributing to habitual abortion.
- Author:
Wen-ling JIANG
1
;
Zhao LIU
;
Zhan-qiu YANG
;
Shun-xian XU
;
Xian-ling LUO
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Habitual; blood; etiology; Adult; Antibodies, Viral; blood; Coxsackievirus Infections; complications; virology; Enterovirus B, Human; immunology; isolation & purification; Female; Humans; Immunoglobulin M; blood; Lymphocytes; ultrastructure; virology; Microscopy, Electron; Pregnancy; Pregnancy Complications, Infectious; blood; virology; RNA, Viral; blood
- From: Journal of Southern Medical University 2006;26(7):1020-1022
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the association of Coxsackie B virus (CBV) with habitual abortion.
METHODSCBV IgM antibody, viral RNA and virions were detected in 86 women with habitual abortion and 40 with induced abortion by means of enzyme-linked immunosorbent assay (ELISA), RT-PCR and virus isolation, respectively.
RESULTSThe positivity rate of CBV IgM were 87.2% and 35% in the two groups, respectively, and the detection rate of the viral RNA was 53.5% and 17.5% in blood lymphocytes, and 59.3% and 17.5% in the placentas. The virions were found in the placentas in 41.9% and 6.9% of the women, respectively. The positivity rates of CBV IgM, viral DNA and virions showed significant difference between the two groups (P<0. 01).
CONCLUSIONCBV might be one of the causes responsible for habitual abortion.
