Clinical observation of target-controlled remifentanil infusion combined with propofol and doxapram in painless artificial abortion.
- Author:
Zhi-min TAN
1
;
Jian-hua LIU
;
Tao DONG
;
Jia-xing LI
Author Information
- Publication Type:Journal Article
- MeSH: Abortion, Induced; Adolescent; Adult; Anesthetics, Combined; Doxapram; administration & dosage; Female; Humans; Infusions, Intravenous; Middle Aged; Piperidines; administration & dosage; Propofol; administration & dosage; Treatment Outcome
- From: Journal of Southern Medical University 2006;26(8):1206-1208
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo observe the impacts of doxapram on anesthetic efficacy and respiratory and circulatory functions during anesthesia with remifentanil given by target-controlled infusion (TCI) combined with propofol in painless artificial abortion.
METHODSA total of 120 ASA I women requiring voluntarily painless artificial abortion were randomized into two equal groups. One group was given remifentanil by TCI at 2 ng/ml and propofol 1mg/kg (group I), and the other given remifentanil by TCI, propofol, and doxapram 0.6 mg/kg (group II). The anesthetic efficacy and respiratory and circulatory suppression during anesthesia were observed.
RESULTSBoth of the two groups showed satisfactory anesthetic efficacy with comparable the BIS values (P>0.05). No significant difference was noted in the induction time and awaking time between the two groups (P>0.05), but group I had more serious respiratory and circulatory depression than group II (P<0.05).
CONCLUSIONDoxapram may attenuate respiratory and circulatory depression during anesthesia with remifentanil given by TCI combined with propofol in painless artificial abortion, and provide comparable anesthetic efficacy.
