Helicobacter pylori induces damage of HepG2 cells in vitro.
- Author:
Ren CHEN
1
;
Xiao-ping CHEN
Author Information
1. Department of Infectious Diseases, Guangdong Provincial People's Hospital, Guangzhou 510080, China.
- Publication Type:Journal Article
- MeSH:
Antigens, Bacterial;
metabolism;
Apoptosis;
physiology;
Bacterial Proteins;
metabolism;
Carcinoma, Hepatocellular;
microbiology;
pathology;
Cell Line, Tumor;
Cell Proliferation;
Cell Survival;
physiology;
Helicobacter pylori;
immunology;
physiology;
Humans;
Liver Neoplasms;
microbiology;
pathology
- From:
Journal of Southern Medical University
2006;26(8):1219-1221
- CountryChina
- Language:Chinese
-
Abstract:
HepG2 cells were treated with Helicobacter pylori (Hp) at different concentrations and the cell killing and apoptosis of the cells were measured with MTT assay and Hoechst 33258 staining technique. The results showed that with the increment of cagA (+) Hp concentration, HepG2 cell killing and apoptosis rate increased in a concentration-dependent manner, but cagA (-) Hp did not significantly impacted on the proliferation and apoptosis of HepG2.
