The Clinical Significance of Serum Creatine Kinase-BB(CK-BB) in Acute Head Injury.
- Author:
Hun Joo KIM
1
;
Soon Ki HONG
;
Chul HUH
;
Yong Pho HAN
Author Information
1. Departments of Neurosurgery, Wonju College of Medicine, Yonsei University, Wonju, Korea.
- Publication Type:Original Article
- Keywords:
Head injury;
Electrophoresis;
Creatine Kinase-BB(CK-BB);
Glasgow Coma Score(GCS);
Glasgow Outcome Score(GOS)
- MeSH:
Back Pain;
Brain;
Cerebral Hemorrhage;
Coma;
Contusions;
Craniocerebral Trauma*;
Creatine*;
Electrophoresis;
Head*;
Humans;
Incidence;
Phosphotransferases;
Skull Fractures
- From:Journal of Korean Neurosurgical Society
1991;20(4):208-217
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
Serial enzymatic determinations by electrophoresis were confined in serum of CK-BB(creatine kinase brain fraction), which were performed on 150 patients with acute head injury. The purpose of this study was to re-evaluate the usefulness of this serum enzyme value as a prognostic correlates. The results obtained are as follows : 1) 125 cases(83.3%) among 150 cases with head injury were revealed as CK-BB positive finding, whereas 25 cases (16.7%) with negative results have generally good outcome. 2) 3 cases (11.5%) of false positive finding were shown among 26 control group with back pain. 3) The maximum value of CK-BB(CK-BBmax) was een within 1st day(38.4%), and 3rd days (80.8%) following injury. 4) The appearance of mean CK-BBmax had two varieties of peak incidence on 1st-and 4th day following injury. 5) The Glasgow Coma Scale(GCS) Score on admission had close relationship to the value of inital CK-BB(CK-BBin) and CK-BBmax, respectively (P<0.001). 6) The ratio of mean value between CK-BBin and CK-BBmax had statistical significance in cases of skull fracture and contusional and/or intracerebral hemorrhage, respecitively (P<0.05, P<0.001). 7) The significant correlation of mean CK-BBin> or =1 IU.L) to outcome (P<0.003) was shown, whereas mean CK-BBmax> or =1 IU/L) to outcome did not (P=0.126). 8) The Glasgow Outcoem Scale (GOS) was strongly correlated to mean GCS Score (P<0.000) and mean CK-BBin (P<0.000), but not to mean CK-BBmzs (P<0.139). 9) The correlationship between mean value of CK-BBin and CK-BBmax was statistically significant only in good recovery and moderate disability group, respectively (P<0.000 & P<0.003).
