Cloning of the full-length genome of A recombinant hepatitis B virus strain and phylogenetic analysis.
- Author:
Tao BIAN
1
;
Li-ping SHEN
;
Feng WANG
;
Yue WANG
;
Li Wen ZHANG
;
Yong ZHANG
;
Sheng-li BI
Author Information
1. National Institute for Viral Disease Control and Prevention, Beijing 100052, China.
- Publication Type:Journal Article
- MeSH:
Cloning, Molecular;
Genome, Viral;
Hepatitis B virus;
classification;
genetics;
Phylogeny;
Recombination, Genetic
- From:
Chinese Journal of Virology
2008;24(4):255-259
- CountryChina
- Language:Chinese
-
Abstract:
An aberrant genotype of hepatitis B virus was discovered from a female child when we surveyed the status of the virus' infection in Guangxi of China. The full-length genome was amplified and sequenced. The length of genome is 3215 bp and the serotype of the virus is adr. In phylogenetic tree analysis with the standard genotype sequence of GenBank, the genome was clustered with genotype C, however, phylogenetic tree analysis of the individual segment supported recombination strain was formed. The segment between nt 1630 and 2880 was similar to genotype C, and the other part of genome close to genotype A. The result suggests it is a recombinant virus strain. The finding provides a reference to study the genotype and evolution of hepatitis B virus in China.
