Surveillance for occult HBV infection and HBsAg variants in blood donors.
- Author:
Chang-rong CHEN
1
;
Quan YUAN
;
Sheng-xiang GE
;
Shan-hai OU
;
Hong-ying NI
;
Yong-chang ZHANG
;
Bin PEI
;
An LI
;
Qiang YAN
;
Yong-cai LIN
;
Qing-rui CHEN
;
Ning-shao XIA
;
Jun ZHANG
Author Information
1. Xiamen Blood Services, Xiamen 361004, China. zxxz@public.xm.fj.cn
- Publication Type:Journal Article
- MeSH:
Adolescent;
Adult;
Blood Donors;
China;
epidemiology;
DNA, Viral;
genetics;
Female;
Genotype;
Hepatitis B;
epidemiology;
immunology;
virology;
Hepatitis B Surface Antigens;
genetics;
immunology;
Hepatitis B virus;
classification;
genetics;
immunology;
physiology;
Humans;
Immunologic Tests;
Male;
Mutation;
Sequence Alignment;
Sequence Analysis, DNA;
Young Adult
- From:
Chinese Journal of Virology
2009;25(3):178-184
- CountryChina
- Language:Chinese
-
Abstract:
Occult hepatitis B virus (HBV) infection status of blood donors in a southern city in China was investigated by immunological assays and nucleic acid testing. Overall, 17 (0.19%, 95% CI: 0.11%-0.30%) of the 9023 HBsAg negative samples were found to be positive for the presence of HBV DNA. "A" epitope sequences were obtained from 14 among them. Mutation(s) in aa124-aa147 existed in 6 (42.9%, 6/14) samples and 4 (66.7%, 4/6)were G145R mutation. Ratio of genotype C in occult donors (10/17) was statistically higher than HBs-positive donors (0/15, P<0.01), which implied that HBV genotype C leaded to occult infection more easily.
