Effects of fluvastatin on blood levels of inflammatory cytokines in patients with unstable angina undergoing percutaneous coronary intervention.
- Author:
Qing-shan SHEN
1
;
Yong-sheng LIU
;
Rui ZHU
;
Du-guan FU
;
Yong-qian TANG
;
Hong TAO
;
Su-zhen LI
;
Jian-wen YE
Author Information
- Publication Type:Journal Article
- MeSH: Angina, Unstable; blood; drug therapy; Anticholesteremic Agents; therapeutic use; C-Reactive Protein; metabolism; Fatty Acids, Monounsaturated; therapeutic use; Humans; Indoles; therapeutic use; Troponin I; blood; Tumor Necrosis Factor-alpha; blood
- From: Chinese Journal of Cardiology 2005;33(4):320-322
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the effect of fluvastatin on blood levels of c-reactive protein (CRP), tumor necrosis factor alpha (TNFalpha) and cardiac troponin I (cTnI) in patients with unstable angina undergoing percutaneous coronary intervention (PCI).
METHODSSixty patients who underwent PCI from July 2002 to April 2004 in our hospital were randomized into two groups: control group; fluvastatin group (40 mg/d). Serum levels of CRP, TNFalpha and cTnI were measured before and after two weeks treatment (in the early morning of the procedure) and at 24 hours after the procedure.
RESULTSThe serum levels of CRP, TNFalpha and cTnI in fluvastatin group were distinctly lower than those in control group before (P < 0.01) and after the procedure (P < 0.01), respectively.
CONCLUSIONThe result suggested that PCI could lead to a detectable increase in serum levels of CRP, TNFalpha and cTnI in patients with coronary heart disease; Fluvastatin could significantly decrease the serum levels of CRP, TNFalpha and cTnI in patients with coronary heart disease; Fluvastatin could also decrease the serum levels of CRP, TNFalpha and cTnI in patients with PCI.
