Effects of delayed opening of infarct-related artery on late left ventricular remodeling in patients with acute anterior myocardial infarction.
- Author:
Li-kun MA
1
;
Hua YU
;
Xiang-yang HUANG
;
Jun ZHU
;
Ke-fu FENG
;
Shi-guang LI
;
Xiao-hong ZHANG
;
Zheng-bin SHAO
;
Xiao-mei DING
;
Ji YAN
;
Tong-yuan GU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Angioplasty, Balloon, Coronary; Female; Humans; Male; Middle Aged; Myocardial Infarction; pathology; physiopathology; therapy; Myocardial Reperfusion; Ventricular Remodeling
- From: Chinese Journal of Cardiology 2005;33(4):328-331
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo assess the effect of delayed opening of the infarct-related artery (IRA) by percutaneous coronary intervention (PCI) on the late left ventricular remodeling after acute anterior myocardial infarction (AAMI).
METHODSSixty four patients with initial Q-wave AAMI and with the total occluded IRA conformed by angiogram at 9.1 +/- 2.3 (2 - 14) days after the onset were divided into successful PCI group and control group (not receiving PCI or the IRA not re-opened). Two-D echocardiogram was performed at acute phase (about 3 weeks), 2 and 6 months after onset of AAMI respectively to detect the left ventricular function and left ventricular wall motion abnormality (VWMA). The total congestive heart failure events were recorded during 6 months follow-up.
RESULTSVWMA scores, left ventricular ejection fraction (LVEF), left ventricular end-diastolic and end-systolic volume indexes (LVEDVI and LVESVI) were similar in 2 groups at acute phase and 2 months after the onset of AAMI. There were no differences between the parameters above at acute phase and 2 months in each group too. VWMA scores and LVEF did not changed significantly at 6 months in each group compared with those at acute phase and 2 months (P > 0.05). But LVEDVI and LVESVI were significantly smaller in the successful PCI group than those in the control group (P < 0.01, P < 0.05). The rate of congestive heart failure events was 19% in control group and 2.0% in successful PCI group (P > 0.05) respectively.
CONCLUSIONSDelayed opening of IRA in AAMI could prevent the late phase but not the early phase of left ventricular remodeling after AMI.