The relationship between expressions of beta1-, beta2-, beta3-adrenoceptor mRNA of myocardium and cardiac function in patients with heart failure.
- Author:
Zhen-kui LI
1
;
Shan-jun ZHU
;
Lin-jun YU
;
Ying TIAN
;
Yi-zhong ZHOU
;
Jiang WANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Case-Control Studies; Female; Heart Failure; genetics; metabolism; physiopathology; Humans; Male; Middle Aged; RNA, Messenger; metabolism; Receptors, Adrenergic, beta-1; genetics; metabolism; Receptors, Adrenergic, beta-2; genetics; metabolism; Receptors, Adrenergic, beta-3; genetics; metabolism
- From: Chinese Journal of Cardiology 2005;33(4):351-353
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the alteration of expressions of beta(1)-, beta(2)-, beta(3)-adrenoceptor mRNA in human myocardial tissue and the relation between their expressions and cardiac function in patient with heart failure.
METHODSThe mRNA expressions of beta(1)-, beta(2)- and beta(3)-adrenergic receptors in myocardial tissue were analyzed by using the reverse transcriptase-polymerase chain reaction in 24 patients with heart failure of valvular heart disease and 5 control subjects.
RESULTSBeta(1)-adrenergic receptor mRNA expressions in myocardium were significantly lower in patients with heart failure than those in control subjects, and progressively reduced with aggravation of heart function. By contrast, beta(3)-adrenoceptor mRNA expressions were significantly higher in patients with heart failure than those in controls, and progressively elevated with aggravation of cardiac function. No difference was observed in beta(2)-adrenergic receptor among all groups.
CONCLUSIONThe changes of beta-adrenergic receptor mRNA expression are associated with the severity of heart failure.
