Relation between the angiotensin II type 2 receptor polymorphism and essential hypertension in men.
- Author:
Wei-wei QIAO
1
;
Kui-xing ZHANG
;
Tong-bao LIU
;
Guo-xiang LIU
;
Shi-jie XU
Author Information
- Publication Type:Journal Article
- MeSH: Asian Continental Ancestry Group; genetics; Gene Frequency; Humans; Hypertension; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptor, Angiotensin, Type 2; genetics
- From: Chinese Journal of Cardiology 2005;33(7):592-594
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify single nucleotide polymorphisms (SNP) of the angiotensin II type 2 receptor (AGTR2) gene, and to determine whether the AGTR2 polymorphisms are associated with essential hypertension in a male Chinese population.
METHODSDirect DNA sequencing was performed in 20 subjects. 96 male hypertensive patients and 107 normal controls were included to assess the contribution of the SNP of AGTR2 gene to hypertension.
RESULTSSeven SNP of the AGTR2 gene were identified, of which 4 were reported for the first time. A case-control study including two polymorphisms (A1675G and T1334C) showed a significant increase in the A1675 allele frequency among male hypertensive subjects as compared with normotensive subjects (49.0% vs 34.6%, P < 0.05).
CONCLUSIONThe AGTR2 A1675G polymorphism might be involved in the development of essential hypertension in male Chinese.
