Relationship between the aldosterone synthase (CYP11B2)-344C/T polymorphism and small artery compliance.
- Author:
Xin-li LI
1
;
Li-rong LIANG
;
Chun-hui NI
;
Zhen-zhen WANG
;
Ai-ping LI
;
Jing LIAO
;
Jian-wei ZHOU
;
Ke-jiang CAO
;
Jun HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Arterioles; physiology; Cytochrome P-450 CYP11B2; genetics; Elasticity; Female; Humans; Male; Middle Aged; Polymorphism, Single Nucleotide
- From: Chinese Journal of Cardiology 2005;33(7):599-602
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between the aldosterone synthase (CYP11B2)-344C/T polymorphism and small artery compliance (C(2)).
METHODSC(2) was measured by CVProfilor DO-2020 in 224 subjects, including 123 subjects with an abnormal C(2) and 101 normal controls. Genotypes of CYP11B2 were determined by polymerase chain reaction-based restriction fragment length polymorphism analysis.
RESULTSThe frequencies of the CYP11B TT genotype and T allele in subjects with an abnormal C(2) were slightly higher than in normal controls, but the differences did not reach statistical significance (55.3% vs 41.6%, P > 0.05, 75.6% vs 66.8%, P > 0.05. However, when CT was combined with CC, the frequency of TT in subjects with an abnormal C(2) was significantly higher than in normal controls (P < 0.05). By CANOVA, TT subjects had a lower C(2) than CT and CC subjects (P < 0.05). Logistic regression analysis revealed that TT genotype was associated with abnormal C(2) (P = 0.043, OR = 1.93 95% CI 1.02-3.63).
CONCLUSIONSThe CYP11B-344C/T polymorphism is associated with small artery compliance, and TT subjects are susceptible to abnormality of small arterial compliance.
