Association of angiotensin II receptor type 1 gene single nucleotide polymorphism with Chinese essential hypertension complicated with coronary heart disease.
- Author:
Kui-xing ZHANG
1
;
Tong-bao LIU
;
Qiu-xia XU
;
Ding-liang ZHU
;
Wei HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Alleles; Asian Continental Ancestry Group; genetics; Case-Control Studies; China; Coronary Disease; complications; genetics; DNA Primers; Female; Humans; Hypertension; complications; genetics; Male; Middle Aged; Polymorphism, Single Nucleotide; Receptor, Angiotensin, Type 1; genetics
- From: Chinese Journal of Cardiology 2005;33(8):720-723
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify the genetic variants of angiotensin II type 1 receptor (AT1) gene in a population of Han ethnicity in east China and to determine whether the AT1 gene polymorphisms are associated with essential hypertension (EH) and coronary heart disease (CHD).
METHODSThe detection of single nucleotide polymorphisms (SNPs) was performed in 20 subjects by a direct DNA sequencing. All 213 EH patients, 171 patients of EH with CHD and 200 controls were genotyped by three detected SNPs.
RESULTSEight positive SNPs were detected in the promoter, exon and 3' untranslated region (3'UTR) of AT1 gene. A case-control study by using a frequent SNP (A-153G) in the promoter region, showed a significant increase in allele frequency of G-153 in the subjects of EH complicated with CHD (17.8% vs 11.5% for normal controls, P < 0.05). The SNP A1166C, which has been widely studied, manifested no difference in the three groups.
CONCLUSIONA polymorphism in the promoter region (A-153G) of AT1 gene might be involved in the development of EH and CHD in Han ethnicity population in east China.
