Treatment of late-staged pancreatic carcinoma with implantation of 125I seeds in combination with regional arterial infusion chemotherapy.
- Author:
Kai-xing AI
1
;
Qi ZHENG
;
Yang XIA
;
Xin-yu HUANG
;
Jian-hua ZOU
;
Jun YAN
;
Jiang-yong MAO
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Antineoplastic Combined Chemotherapy Protocols; therapeutic use; Brachytherapy; adverse effects; methods; Chemotherapy, Adjuvant; Combined Modality Therapy; Female; Follow-Up Studies; Humans; Infusions, Intra-Arterial; Iodine Radioisotopes; therapeutic use; Male; Middle Aged; Pancreatic Neoplasms; therapy; Retrospective Studies; Survival Analysis; Treatment Outcome
- From: Chinese Journal of Surgery 2007;45(1):27-29
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the effect of combined use of implantation of (125)I seeds with regional arterial infusion chemotherapy on late-staged pancreatic carcinoma.
METHODSDuring operation, (125)I seeds were implanted into tumor parenchyma or operative beds for 7 patients with pathological diagnosis of late-staged pancreatic carcinoma, then chemotherapy pump was implanted into common hepatic artery or celiac artery through left gastric artery or right epigastric artery. Gemcitabine (1000 mg/m(2)) plus fluorouracil (500 mg/m(2)) was used for postoperative adjuvant chemotherapy once a week for 7 consecutive weeks.
RESULTSThe mean number of implanted (125)I seeds was 42 and the mean dose was 29.4 mCi. The mean follow-up time was 245 days. Rate of pain relief was 100%, metastasis foci was reduced in 2 cases. CA-19-9 Antigen level decreased to normal in all patients. Pancreatic fistula occurred in one case and was cured with conservative therapy.
CONCLUSIONSThe combination therapy is effective for late-staged pancreatic carcinoma, it brings symptom relief and improvement in quality of life.
