Change of IFN-g and TNF-a Producing Capacity in the Course of Chemotherapy in Patients with Pulmonary Tuberculosis.
10.4046/trd.2000.48.2.149
- Author:
Jae Joon YIM
1
;
Sang Min LEE
;
Jae Ho LEE
;
Chul Gyu YOO
;
Choon Taek LEE
;
Hee Soon CHUNG
;
Young Whan KIM
;
Sung Koo HAN
;
Young Soo SHIM
Author Information
1. Department of Internal Medicine and Lung Institute, Seoul National University College of Medicine, Seoul, Korea.
- Publication Type:Original Article
- Keywords:
tuberculosis;
interferon-gamma;
tumor necrosis factor-alpha
- MeSH:
Classification;
Drug Therapy*;
Humans;
Interferon-gamma;
Mycobacterium tuberculosis;
Tuberculosis;
Tuberculosis, Pulmonary*;
Tumor Necrosis Factor-alpha
- From:Tuberculosis and Respiratory Diseases
2000;48(2):149-154
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND: Interferon-gamma (IFN-g) and tumor necrosis factor-alpha (TNF-a) play a critical role in protective immunity against Mycobacterium tuberculosis infection. (The change )of IFN-g and TNF-a producing capacity in the course of antituberculous chemotherapy in patients with pulmonary tuberculosis (was evaluated in this study.) METHOD: In 29 patients with pulmonary tuberculosis, phytohemagglutinin(PHA) or purified protein derivative(PPD) stimulated production of IFN-g and TNF-a by peripheral blood mononuclear cells was quantified. Five patients were sampled before they underwent antituberculous treatment, 11 patients after 0 -4 months, six after 4 -completion and seven after treatment completion. RESULT: There was no difference in PHA- or PPD- stimulated production of IFN-g and TNF-a between each group. CONCLUSION: No difference in PHA- or PPD- stimulated production of IFN-g and TNF-a between two groups could be identified during classification of patients with pulmonary tuberculosis by their treatment stages.
