Experimental study on an auditory method for analyzing DNA segments.
- Author:
Shouzhong XIAO
1
;
Xianglin FANG
Author Information
1. Ba-Jing Medical Informatics Institute, Chongqing University, Changqing 400044.
- Publication Type:Journal Article
- MeSH:
Computational Biology;
methods;
Decision Making, Computer-Assisted;
Genome;
Humans;
Multimedia;
Sequence Analysis, DNA;
methods;
Sound
- From:
Journal of Biomedical Engineering
2002;19(1):172-177
- CountryChina
- Language:Chinese
-
Abstract:
To explore a new method for analyzing biological molecules that have already been sequenced, an experimental study on an auditory method was carried out. The auditory method for analyzing biological molecules includes audible representation of sequence data. Audible representation of sequence data was implemented by using a multimedia computer. Each mononucleotide in a DNA sequence was matched with a corresponding sound, i.e., a DNA sequence was "dubbed" in a sound sequence. When the sound sequence is played, a special cadence can be heard. In the audible representation experiment, special cadences of different exons can be clearly heard. The results show that audible representation of DNA sequence data can be implemented by using a multimedia technique. After a 5-time auditory training, subjects both in internal testing and external testing can obtain 93%-100% of judgment accuracy rate for the difference between two sound sequences of two different exons, thus providing an experimental basis for the practicability of this method. Auditory method for analyzing DNA segments might be beneficial for the research in comparative genomics and functional genomics. This new technology must be robust and be carefully evaluated and improved in a high-throughput environment before its implementation in an application setting.
