Expression and clinical significance of MAGE-4 gene in human hepatocellular carcinoma.
- Author:
Haitao ZHAO
1
;
Jing'an RUI
;
Xu CONG
;
Yi ZHAO
;
Shaobin WANG
;
Shuguang CHEN
;
Yu WANG
;
Yu WANG
;
Xisheng LENG
;
Weifeng CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Antigens, Neoplasm; Carcinoma, Hepatocellular; genetics; pathology; Gene Expression Regulation, Neoplastic; Humans; Liver Neoplasms; genetics; pathology; Neoplasm Proteins; genetics; RNA, Neoplasm; genetics; Reverse Transcriptase Polymerase Chain Reaction
- From: Chinese Journal of Hepatology 2002;10(2):100-102
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the possibility of MAGE-4 gene encoding protein used as a target for immunotherapy in HCC patients.
METHODSThe expression of MAGE-4 gene in tumor tissues and tumor adjacent non-HCC liver tissues was examined by the RT-PCR method. The relationship between positive expression rate of MAGE-4 gene and other clinical and lab data including AFP, AFU, anti-HCV, HBsAg, AFP mRNA, and the diameter of the tumors in HCC patients was also determined.
RESULTSThe positive expression rate of MAGE-4 gene was significantly higher in the tumor than in tumor surrounding tissues (38.7% vs 0%, P<0.01), while the positive expression rate of MAGE-4 gene had no relationship with the clinical and lab data (P>0.05).
CONCLUSIONSThe high frequency of MAGE-4 gene expression in HCC suggests the possibility of MAGE-4 gene encoding protein as a target for immunotherapy in HCC patients, but the expression has no relationship with the tumor metastasis and the recurrence of HCC.
