Relationship between plasma carbon monoxide and blood-brain barrier permeability in cirrhotic rats.
- Author:
Shuping YANG
1
;
Jiyao WANG
;
Boming HE
;
Guoding FANG
;
Rong FU
;
Xiancheng CHEN
Author Information
- Publication Type:Journal Article
- MeSH: Alanine Transaminase; blood; Animals; Aspartate Aminotransferases; blood; Blood Pressure; physiology; Blood-Brain Barrier; physiology; Capillary Permeability; physiology; Carbon Monoxide; blood; Carbon Tetrachloride; Heart Rate; physiology; Liver Cirrhosis, Experimental; blood; chemically induced; physiopathology; Male; Rats; Rats, Sprague-Dawley; gamma-Glutamyltransferase; blood
- From: Chinese Journal of Hepatology 2002;10(2):129-131
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the relationship between plasma levels of carbon monoxide and blood-brain permeability in cirrhotic rats.
METHODSWe measured mean arterial pressure (MAP), heart rate, plasma levels of carbon monoxide and amount of Evans blue in the brain tissue taken as the index of blood-brain permeability in cirrhotic rats (n=10) and controls (n=10).
RESULTSCirrhotic rats showed significant increases in plasma carbon monoxide and amount of Evans blue in brain tissue compared with controls [(18.37 +/- 1.79) micromol/L,(18.52 +.- 1.39) ng/mg vs (10.27 +/- 1.21) micromol/L, (15.08 +/- 1.06) ng/mg; P< 0.01]. Carbon monoxide levels in cirrhotic rats correlated positively with blood-brain barrier permeability and inversely with MAP (r=0.72, P< 0.01; r= -0.67, P< 0.05).
CONCLUSIONSCarbon monoxide, involving in the occurrence of hypotension and the increase of blood-brain barrier permeability, may play a role in the development of hepatic encephalopathy.
