Vascular Endothelial Growth Factor-C Expression in Primary and Metastatic Brain Tumor.
- Author:
Ji Hun CHUNG
1
;
Tae Sik KONG
;
Myoung Jae KANG
;
Dong Geun LEE
;
Myoung Ja CHUNG
Author Information
1. Department of Neurosurgery, Presbyterian Medical Center, Jeonju, Korea. mjchung@moak.chonbuk.ac.kr
- Publication Type:Original Article
- Keywords:
Primary brain tumor;
Metastatic brain tumor;
VEGF-C;
VEGF
- MeSH:
Brain Neoplasms*;
Brain*;
Coloring Agents;
Humans;
Lymphangiogenesis;
Lymphatic Vessels;
Vascular Endothelial Growth Factor A;
Vascular Endothelial Growth Factor C*
- From:Journal of Korean Neurosurgical Society
2002;32(6):543-547
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
OBJECTIVE: Vascular endothelial growth factor(VEGF)-C is involved in lymphangiogenesis and spreading of cancer cells via lymphatic vessels. The aim of the present study is to investigate the relationship between the absence of cerebral lymphatic vessels and low metastatic rate of brain tumors. METHODS: Immunohistochemical stains were performed for VEGF-C and VEGF in surgically resected specimens from 57 patients with primary(38 cases, low grade : 10 cases, high grade : 28 cases) and metastatic(19 cases) brain tumor. RESULTS: The expression of VEGF-C was higher in metastatic carcinoma(68%) than in high-grade primary tumor(29%). There was no difference for VEGF expression between high grade brain tumor (71%) and metastatic carcinoma(58%). CONCLUSION: Low VEGF-C expression of primary brain tumors may play a role in low metastatic rate of brain tumors.
