Increased subthalamic neuronal activity after dorsal raphe nucleus lesion by 5,7-dihydroxytryptamine in the rat.
- Author:
Jian LIU
1
;
Yu-Xia CHU
;
Jie FENG
;
Yong WANG
;
Qiao-Jun ZHANG
;
Lin-Ping XU
Author Information
1. Department of Physiology, School of Medicine, Xi'an Jiao Tong University, Xi'an 710061, China. liujian@mail.xjtu.edu.cn
- Publication Type:Journal Article
- MeSH:
5,7-Dihydroxytryptamine;
pharmacology;
Adrenergic Agents;
pharmacology;
Animals;
Electrophysiological Phenomena;
Male;
Neurons;
physiology;
Random Allocation;
Raphe Nuclei;
drug effects;
pathology;
Rats;
Rats, Sprague-Dawley;
Subthalamic Nucleus;
physiopathology
- From:
Acta Physiologica Sinica
2005;57(1):83-90
- CountryChina
- Language:Chinese
-
Abstract:
In vivo extracellular recordings were made in the subthalamic nucleus (STN) of intact control rats and rats with 5,7-dihydroxytryptamine (5,7-DHT) -produced lesion of dorsal raphe nucleus (DRN). The results showed that the firing rate of STN neurons in control rats and DRN-lesioned rats were (6.93+/-6.55) Hz and (11.27+/-9.31) Hz, respectively, and the firing rate of DRN-lesioned rats significantly increased when compared to the control rats (P<0.01). In control rats, 13% of STN neurons discharged regularly, 46% irregularly and 41% in bursts. In DRN-lesioned rats, 9% of STN neurons discharged regularly, 14% irregularly and 77% in bursts, the percentage of STN neurons firing in bursts was obviously higher than that of the control rats (P<0.01). In addition, the mean interspike interval coefficient of variation of STN neurons in control rats and DRN-lesioned rats were (0.05+/-0.04) and (0.11+/-0.09), respectively. The mean interspike interval coefficient of variation of DRN-lesioned rats was significantly higher than that of the control rats (P<0.001). These results show that the firing rate and the bursting pattern rate of neurons in STN of DRN-lesioned rats increase significantly, suggesting that DRN inhibits the neuronal activity of the subthalamic neurons in the intact rat.
