Effect of microinjection of atrial natriuretic peptide into the paraventricular nucleus on baroreflex sensitivity in conscious rats.
- Author:
Hai-Ying JIANG
1
;
Qing-Hua JIN
;
Ying-Jun LI
;
Dong-Yuan XU
;
Yuan-Zhe JIN
;
Xiu-Ji JIN
Author Information
1. Department of Physiology, Yanbian University Medical School, Yanji 133000, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Atrial Natriuretic Factor;
pharmacology;
physiology;
Baroreflex;
drug effects;
physiology;
Male;
Microinjections;
Paraventricular Hypothalamic Nucleus;
physiology;
Random Allocation;
Rats;
Rats, Wistar
- From:
Acta Physiologica Sinica
2005;57(2):175-180
- CountryChina
- Language:Chinese
-
Abstract:
The role of atrial natriuretic peptide (ANP) in the central regulation of the circulation is known to be a neurotransmitter or a neuromodulator, but its actions on baroreceptor reflex function are not fully resolved. The present study examined the role of ANP (6, 60 ng/0.2 microl) by direct microinjection into the hypothalamic paraventricular nucleus (PVN) in conscious rats. OPC-21268 (0.45 microg/3 microl), an antagonist of the V(1) receptor, was microinjected into the lateral ventricle to examine whether the effect of ANP on baroreflex sensitivity is mediated by vasopressin (VP). ANP significantly increased the baroreflex sensitivity, and OPC-21268 attenuated the increase of baroreflex sensitivity induced by ANP. Intravenous injections of ANP (60 ng/0.04 ml) did not affect baroreflex sensitivity. These results suggest that ANP in the PVN may produce a facilitative effect on baroreflex, and the effect may be via, at least in part, the central vasopressin.
