Acute pancreatitis induced by cyclosporine a following allogeneic hematopoietic stem cell transplant.
- Author:
Rong GUO
1
;
Xin DU
;
Jian-Yu WENG
;
Cheng-Xin DENG
;
Sui-Jing WU
;
Cheng-Wei LUO
Author Information
1. Department of Hematology, Guangdong Provincial People Hospital, Guangzhou 510080, Guangdong Province, China. gh7311@yahoo.com.cn
- Publication Type:Case Reports
- MeSH:
Cyclosporine;
adverse effects;
Female;
Hematopoietic Stem Cell Transplantation;
adverse effects;
Humans;
Middle Aged;
Pancreatitis, Acute Necrotizing;
chemically induced;
Postoperative Complications;
chemically induced
- From:
Journal of Experimental Hematology
2009;17(2):472-475
- CountryChina
- Language:Chinese
-
Abstract:
Pancreatitis has not been reported in allogeneic stem cell transplant (allo-SCT) recipients with cyclosporine in China. This article presented a case of acute pancreatitis in a 49-year-old patient with AML-M2a who received allogeneic stem cell transplant from her HLA identical sister. The preparative regimen consisted of busulfan and cyclophosphamide. The cyclosporine A, short-term methotrexate and antilymphocyte globulin (ATG), were used to prevent the graft-versus-host disease (GVHD). Clinical and laboratory signs of acute pancreatitis were found in the patient on day 20 post-transplant. A diagnosis of acute pancreatitis was made although the pancreas was apparently normal at abdominal contrast-enhanced tomography and ultrasonography. She recovered with supportive care and reduction of cyclosporine dose. In conclusion, cyclosporine is the probable cause of pancreatitis in this patient.
