Advance of study on MN1 gene in acute myeloid leukemia - review.
- Author:
Hai-Ming SUN
1
;
Si-Xuan QIAN
;
Jian-Yong LI
Author Information
1. Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China.
- Publication Type:Journal Article
- MeSH:
Humans;
Leukemia, Myeloid, Acute;
genetics;
Oncogene Proteins, Fusion;
genetics;
Transcription Factors;
genetics;
Tumor Suppressor Proteins;
genetics
- From:
Journal of Experimental Hematology
2009;17(2):504-508
- CountryChina
- Language:Chinese
-
Abstract:
The transcriptional coactivator MN1 has been identified as a gene overexpressed in certain types of human acute myeloid leukemia. Overexpression of this gene is associated with all inv (16) AML, retinoic acid-resistance, a worse prognosis as well as a shorter survival in AML patients with a normal karyotype. This article reviews the role of MN1 in acute myeloid leukemia including MN1 gene structure and action mechanism, MN1-TEL and AML with normal karyotype, MN1 and inv (16) AML, MN1 and retinoic ocid-resistance, and so on.
