Progress of study on relationship between Mcl-1 gene and hematologic malignancies - review.
- Author:
Zhi-Hui LI
1
;
Hui-Min LI
Author Information
1. Department of Hematology, Yunnan Second People Hospital, Kunming 650021, Yunnan Province, China.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Gene Expression Regulation, Neoplastic;
Humans;
Leukemia;
genetics;
Lymphoma;
genetics;
Multiple Myeloma;
genetics;
Myeloid Cell Leukemia Sequence 1 Protein;
Proto-Oncogene Proteins c-bcl-2;
genetics;
Signal Transduction
- From:
Journal of Experimental Hematology
2009;17(2):509-512
- CountryChina
- Language:Chinese
-
Abstract:
Mcl-1 (myeloid cell leukemia-1) is a member of Bcl-2 (B cell leukemia-2) family, which may play an important role in cell apoptosis regulation, occurrence and development of tumors. This paper reviews advance of studies on the function of the mcl-1 gene and MCL-1 protein, the signal transduction pathways (JAK/STAT, MAPK, PI-3K) regulating the expression of mcl-1 gene, and the relationship between mcl-1 gene and hematologic malignancies.
