Mechanism of donor T cell migration and homing in the pathophysiology of acute graft-versus-host disease - review.
- Author:
Li-Xia SUN
1
;
Han-Yun REN
Author Information
1. Department of Hematology, Beijing University First Hospital, Beijing 100034, China.
- Publication Type:Journal Article
- MeSH:
Cell Movement;
Graft vs Host Disease;
Humans;
Receptors, Lymphocyte Homing;
T-Lymphocytes;
cytology;
immunology
- From:
Journal of Experimental Hematology
2009;17(2):519-522
- CountryChina
- Language:Chinese
-
Abstract:
Migration of donor T cells to the host second lymphoid organs and homing of activated donor T cells into the target tissues play crucial role in the pathophysiology of acute graft-versus-host disease (aGVHD). More deep understanding of the mechanisms for donor T cell migration and homing reveals an important significance in preventing the initiation of aGVHD. In this review, the migration of donor T cells to host second lymphoid organs, homing of donor activated T cells into the target organs, homing of regulating T cells into target organs, the mechanisms of T cell migration and homing in process of aGVHD and its study prospects were summarised.
