Relationship between polymorphisms of FCGR2B and susceptibility of children idiopathic thrombocytopenic purpura.
- Author:
Li-Ya HE
1
;
Yu-Jun HUANG
;
Dong-Bo LAI
;
Ming-Bo ZHAO
;
Wen-Ying ZHANG
;
Tao XU
;
Jia-Yi WANG
;
Jun SHI
;
Yu-Hong ZHAO
;
Xiu-Xian XU
Author Information
1. Department of Hematology & Oncology, Guangzhou Children's Hospital, Guangzhou, Guangdong Province, China. linhly@126.com
- Publication Type:Journal Article
- MeSH:
Alleles;
Case-Control Studies;
Child;
Child, Preschool;
Gene Frequency;
Genetic Predisposition to Disease;
Genotype;
Humans;
Infant;
Polymorphism, Genetic;
Purpura, Thrombocytopenic, Idiopathic;
genetics;
Receptors, IgG;
genetics
- From:
Journal of Experimental Hematology
2009;17(3):729-733
- CountryChina
- Language:Chinese
-
Abstract:
The aim of study was to investigate the relationship between polymorphisms of FCGR2B232 1/T oligonucleotide and the susceptibility of children with idiopathic thrombocytopenic purpura (ITP). DNA from 76 patients with ITP and 37 controls was extracted. The SNPs of FCGR2B-232 was detected by polymerase chain reaction (PCR) combined with direct sequencing. The genotype distribution and allele frequency among different groups were compared. The results showed that the genotype (I/I, I/T, T/T) of FCGR2B-232 were 55.3%, 42.1%, and 2.6% in 76 patients with ITP, while 81.1%, 18.9%, 0% in 37 controls. The allele frequencies of FCGR2B-232 in patients with ITP were 76.3% (I232) and 23.7% (T232), but 90.5% and 9.5% in controls. There were significant differences in genotype distributions between the ITP patients and controls (chi(2) = 7.45, = 0.024). The enrichment in Thr232 allele carrier was also significant among the ITP patients as compared with the controls (chi(2) = 7.18, p = 0.007, odds ratio 3.47). There were also significant differences in allele frequencies between the ITP patients and controls [chi(2) = 6.54, p = 0.011, odds ratio 2.97, 95% CI (1.25 - 7.05)]. It is concluded that the polymorphisms of FCGR2B-232 significantly correlates with the susceptibility of children suffering from ITP. The minor Thr232 allele may be a risk genetic factor to ITP children.
