Distribution of tap1 and tap2 loci allelic and genotypic frequencies in Chinese Hans.
- Author:
Wu SHEN
1
;
Tong SHEN
;
Biao YIN
;
Jie-Wei ZHENG
;
Da-Zhuang LIU
;
Ming-Liang FENG
Author Information
1. Shanghai Blood Center, Shanghai, China.
- Publication Type:Journal Article
- MeSH:
ATP-Binding Cassette Sub-Family B Member 2;
ATP-Binding Cassette Transporters;
genetics;
ATP-Binding Cassette, Sub-Family B, Member 3;
Alleles;
Asian Continental Ancestry Group;
genetics;
Gene Frequency;
Genotype;
Haplotypes;
Humans
- From:
Journal of Experimental Hematology
2009;17(3):777-781
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to investigate the distribution and implication of tap1 (transporter associated with antigen processing) and tap2 loci allelic and genotypic frequencies. The distribution of tap1 and tap2 loci allelic and genotypic frequencies in 339 random samples of healthy Chinese Hans was analyzed by TaqMan PCR. Several genetic information about power of discrimination, cumulative DP, polymorphism information content, expected heterozygosity and observed heterozygosity were calculated. The results indicated that 5 tap1 alleles (tap1*0101, 020101, 020102, 0301 and 0401) and 4 tap2 alleles (tap2*0101, 0102, 0103 and 0201) were detected in all samples. 8 tap1 genotypes were found which account for 53.3% of the theoretic genotype and 6 tap2 genotypes were found which account for 60% of the theoretic genotype. The genotyping results of tap1 and tap2 both conform to the Hardy-Weinberg expectations (p > 0.05). Tap1*0101 (79.79%) and tap2*0101 (82.74%) are the most common alleles in Chinese Hans. It is concluded that tap1*0101 and tap2*0101 are most common alleles in Chinese Hans, tap1 and tap2 loci carry some power of individual discrimination and polymorphism information content. These two locl can be used for the research in the fields of human genetics, linkage analysis of genetic disease genes, paternity test and individual identification and so on.
