A total of 362 HLA different haplotypes and HLA recombination haplotypes based on analysis of their family pedigree in Chinese partial Han populations.
- Author:
Su-Qing GAO
1
;
Xi CHENG
;
Qian LI
;
Yu-Zhu LI
;
Zhi-Hui DENG
Author Information
1. Institute of Transfusion Medicine, Shenzhen Blood Center, Shenzhen, Guangdong Province, China. suqinggao@yahoo.com.cn
- Publication Type:Journal Article
- MeSH:
Alleles;
Asian Continental Ancestry Group;
genetics;
Gene Frequency;
HLA Antigens;
classification;
genetics;
HLA-A Antigens;
genetics;
HLA-B Antigens;
genetics;
HLA-DR Antigens;
genetics;
HLA-DRB1 Chains;
Haplotypes;
Humans;
Pedigree;
Recombination, Genetic
- From:
Journal of Experimental Hematology
2009;17(3):782-786
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to discover the novel HLA recombination haplotypes and investigate the distribution of haplotypes in Chinese Han population. Based on the HLA-A, B, DRB1 typing results of 179 family members, 791 haplotypes were assigned by the mode of inheritance. The results showed that a total of 4 novel recombinant haplotypes in HLA-DRB1 locus region were observed in 4 families, which ratio of paternal to maternal chromosomes was 3:1. The recombination ratio between HLA-DRB1 and HLA-A or B loci was 0.92% (4/433). There were a total of 362 kinds of HLA-A, -B, -DRB1 haplotypes to be confirmed in Chinese Han partial population. A33-B58-DR17, A2-B46-DR9, A30-B13-DR7, A11-B13-DR15, A11-B75-DR12 and A2-B46-DR14 were the most common haplotypes that was consistent with the distribution of HLA alleles in unrelated donors. There were A1-B63-DR12, A29-B46-DR15, A1-B61-DR10, A34-B35-DR9, A29-B54-DR4, A23-B13-DR16 and A34-B62-DR15 haplotypes and so on, which were rare haplotypes not yet reported in Chinese. It is concluded that the HLA-A-B-DRB1 haplotypes would be confirmed by analysis of their family pedigree. The results obtained in this study are basic data for study of Chinese anthropology, organ transplantation and disease correlation analysis.
