Expression of Cyclooxygenase-2 and p53 Protein in Colonic Adenoma with Malignant Change.
- Author:
Seok Hyun KIM
1
;
Jae Hoon JUNG
;
Yoon Sae KANG
;
Yeon Soo KIM
;
Ki Oh PARK
;
Yeum Seok LEE
;
Seon Mun KIM
;
Seung Won SEO
;
Jae Kyu SEONG
;
Byung Seok LEE
;
Hyun Yong JEONG
;
Gyu Sang SONG
Author Information
1. Department of Internal Medicine, Chungnam National University College of Medicine, Daejeon, Korea. Jeonghy@cnuh.co.kr
- Publication Type:Original Article
- Keywords:
Colonic adenoma with malignant change;
Cyclooxygenase-2;
p53
- MeSH:
Adenoma*;
Chungcheongnam-do;
Colon*;
Cyclooxygenase 2*;
Genes, p53
- From:Korean Journal of Gastrointestinal Endoscopy
2005;30(3):133-139
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
BACKGROUND/AIMS: The aim of this study was to investigate the value of expression of COX-2 and p53 protein in colonic adenoma with or without malignant change. METHODS: We studied twenty-five cases of colonic adenoma with malignant change and twenty-five cases of colonic adenoma without malignant change treated by colonoscopic polypectomy in Chungnam National University Hospital from January, 1999 to July, 2002. We compared the expression of COX-2 and p53 protein by immunohistochemical stain in both group. RESULTS: In immunohistochemical staining, the expression of COX-2 was demonstrated 68.0% (17 of 25) of colonic adenoma with malignant change and not different with that of colonic adenoma without malignant change. The overexpression of p53 protein was detected immunohistochemically in 88.0% (22 of 25) of colonic adenoma with malignant change and 32% (8 of 25) of colonic adenoma only (p <0.05). CONCLUSIONS: The degree of COX-2 expression was similar in colonic adenoma and colonic adenoma with malignant change, but the expression of p53 in colonic adenoma with malignant change was significantly higher (p <0.05). These results suggest COX-2 might operate on early step of adenoma-carcinoma sequence. Also these results remind us that mutation of p53 gene operates on the late step of adenoma-carcinoma sequence.
