Important role of nitric oxide in stored red blood cells -- review.
- Author:
Chang-Hong ZHANG
1
;
Jun ZHOU
;
Li PANG
Author Information
1. Department of Blood Transfusion, General Hospital, Beijing Military Area, Beijing, China. bzsxk@tom.com
- Publication Type:Journal Article
- MeSH:
Erythrocytes;
metabolism;
physiology;
Hemoglobins;
biosynthesis;
Humans;
Nitric Oxide;
metabolism
- From:
Journal of Experimental Hematology
2009;17(3):831-834
- CountryChina
- Language:Chinese
-
Abstract:
The efflux of nitro oxide (NO) in the duration of storing red blood cells (RBCs) was the main reason resulting in decrease and even loss of vasodilatory activity, cell deformability and ability of carrying oxygen (O2) in the stored RBCs. The deep understanding physical functions and acting ways of NO in circulatory system, as well as transformations and balance control of S-Nitrosohemoglobin (SNO-Hb) has an important significance for ensuring sure safety and efficacy of transfusion. In this article, the physical functions, acting ways, retaining and transferring form of nitro oxide, and SNO-Hb adjusting, as well as effects of SNO-Hb concentration on change on stored red blood cells were reviewed.
