Study on the solid dispersion system of artemisinine
- Author:
Long Van Nguyen
- Publication Type:Journal Article
- Keywords:
artemisinine
- MeSH:
Artemisinine;
Pharmaceutical Preparations;
therapeutics;
Anti-Bacterial Agents
- From:Pharmaceutical Journal
1999;282(10):15-18
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
Enteric solid dispersions of artemisinine were prepared by spray drying using methacrylic acid copolymer (Eudragit L100) as carrier and hydroxypropylmethylcellulose (HPMC), Tween 20, PEG 6000, colloidal silica (aerosil) as additives. Spherical solid dispersion particles were obtained. Both solubility and dissolution rate of artemisinine studied in the medium pH 7.2 from all solid dispersions were markedly improved compared with that from the original or spray dried drug powder. The drug release rate of tablets that were made from the solid dispersion with drug-carrier ratio of 1:2 was nearly unchanged in medium pH 7.2 and was retarded in medium pH 1.5 in comparison with the solid dispersion powder.
