Clinicopathologic features, prognosis and etiology of primary non-Hodgkin lymphoma of bone.
- Author:
Zhi-Yi ZHOU
1
;
Qun-Li SHI
;
Xiao-Jun ZHOU
;
Jian-Yun LAN
;
Jian-Dong WANG
;
Wen-Bin HUANG
;
Jie-Yu CHEN
;
Heng-Hui MA
;
Hang-Bo ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Aged; Bone Neoplasms; genetics; metabolism; pathology; Female; Gene Rearrangement; Genes, bcl-2; Humans; Immunophenotyping; Interferon Regulatory Factors; metabolism; Lymphoma, Large B-Cell, Diffuse; genetics; metabolism; pathology; Lymphoma, Non-Hodgkin; genetics; metabolism; pathology; Male; Middle Aged; Neprilysin; metabolism; Prognosis; Proto-Oncogene Proteins c-bcl-2; metabolism; Proto-Oncogene Proteins c-bcl-6; metabolism; RNA-Binding Proteins; metabolism; Ribosomal Proteins; metabolism; Survival Rate; Young Adult
- From: Chinese Journal of Pathology 2007;36(2):90-93
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the clinicopathologic features, prognostic indicators and possible etiology of primary non-Hodgkin lymphoma of bone (PNHLB).
METHODSThe clinicopathologic features of 17 cases of PNHLB were reviewed. In-situ hybridization for Epstein-Barr virus early RNA (EBER) and polymerase chain reaction for bcl-2/JH gene rearrangement were performed using paraffin-embedded materials. The correlation between serum lactic dehydrogenase level, treatment options, international prognostic indicator (IPI) and immunophenotype with clinical outcome were analyzed.
RESULTSThe majority of the 17 cases studied was diffuse large B-cell lymphoma (94.1%). The 5-year survival rate was 68.8%. Unfavorable prognostic factors included high-risk IPI (P = 0.031) and bcl-2 overexpression (P = 0.028). Treatment options and expression of CD10, MUM-1 or bcl-6 did not correlate with clinical outcome (P > 0.05). Only 1 patient was positive for EBER, as demonstrated by in-situ hybridization.
CONCLUSIONSThe clinical outcome of PNHLB is relatively favorable. IPI and bcl-2 expression may serve as useful prognostic indicators. EBV is likely not related to pathogenesis of this type of lymphoma.
