Expression of translationally controlled tumor protein in human breast cancer and its clinical significance.
- Author:
Si-jie LI
1
;
Hong-yao JIA
;
Di WU
;
Zhi-min FAN
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Aged; Biomarkers, Tumor; metabolism; Breast Neoplasms; metabolism; pathology; Female; Humans; Middle Aged
- From: Journal of Southern Medical University 2011;31(9):1560-1563
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of translationally controlled tumor protein (TCTP) in human breast cancer tissues and its clinical significances.
METHODSThe expression of TCTP in 94 human breast cancer and the corresponding adjacent normal mammary tissues were detected using immunohistochemistry.
RESULTSThe expression rate of TCTP was 64.89% in human breast cancer tissues, significantly higher than that in normal benign mammary tissues (39.36%, P<0.001). TCTP overexpression was positively correlated to the tumor size, clinical stage, lymph node metastasis and histological grade of breast cancer (P<0.05). Patients with positive TCTP expression had a significantly shorter mean survival time than those with negative expression (P<0.001).
CONCLUSIONTCTP may play an important role in the tumorigenesis and development of breast cancer, and can be an important prognostic factor for this malignancy.
