Establishment and evaluation of a modified plasma protamine paracoagulation test.
- Author:
Xu-hua TANG
1
;
Qiang LI
;
Wen-hao LIN
;
Lin FU
;
Qiang WANG
;
Xiao-ping XIE
;
Yu-ming ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Blood Coagulation Tests; methods; Female; Humans; Male; Middle Aged; Protamines; blood; Sensitivity and Specificity; Thrombosis; blood; diagnosis
- From: Journal of Southern Medical University 2011;31(9):1626-1628
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo establish a modified plasma protamine paracoagulation test.
METHODSPlasma protamine paracoagulation, modified plasma protamine paracoagulation and D-dimer (D-D) tests were performed for the plasma samples collected from 98 cases of disseminated intravascular coagulation (DIC) and 156 normal subjects. The sensitivity and specificity of the 3 tests were analyzed. The plasma samples from 8 cases of suspected myocardial infarction were detected using modified plasma protamine paracoagulation for diagnostic purpose.
RESULTSThe sensitivity of plasma protamine paracoagulation, modified plasma protamine paracoagulation and D-D tests was 16.33%, 88.76% and 77.56%, and the specificity was 100%, 88.46% and 97.44%, respectively. Positive results occurred earlier in modified plasma protamine paracoagulation test than in plasma protamine paracoagulation and D-D tests in 5 cases of myocardial infarction.
CONCLUSIONThe modified plasma protamine paracoagulation test has a higher sensitivity than plasma protamine paracoagulation test and a higher specificity than D-D test, and can be helpful in early diagnosis of thrombosis and fibrinolysis.
