Effects of eight environmental endocrine disruptors on insulin resistance in patients with polycystic ovary syndrome: a preliminary investigation.
- Author:
Ting-ting LI
1
;
Liang-zhi XU
;
Yong-heng CHEN
;
Hong-mei DENG
;
Chun-ying LIANG
;
Ying LIU
;
Xiao-fang LIU
;
Jing ZHANG
;
De-ying KANG
;
Dong-sheng QIU
;
Dai-wen HAN
;
Rong HU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Benzhydryl Compounds; adverse effects; blood; Case-Control Studies; Endocrine Disruptors; adverse effects; blood; Environmental Pollutants; adverse effects; blood; Female; Humans; Insulin Resistance; Phenols; adverse effects; blood; Phthalic Acids; adverse effects; blood; Polycystic Ovary Syndrome; blood; physiopathology; Young Adult
- From: Journal of Southern Medical University 2011;31(10):1753-1756
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the relationship between 8 endocrine-disrupting chemicals in the serum and insulin resistance in patients with polycystic ovary syndrome (PCOS).
METHODSThis study was conducted among 60 patients with PCOS, including 23 with insulin resistance (PCOS-IR) and 37 without insulin resistance (PCOS-NIR), and 29 non-PCOS women seeking medical attention for infertility or menstrual disorder (control group). The serum levels of 6 phthalic acid esters (PEAs), bisphenol A (BPA) and octylphenol (OP) were measured in all the subjects.
RESULTSThe levels of PAEs, BPA and OP showed no significant differences between PCOS patients and the control group (P>0.05). The serum level of OP was significantly lower in patients PCOS-IR than in those with PCOS-NIR (47.89 ng/ml vs 60.24 ng/ml, P<0.05).
CONCLUSIONPEAs and BPA do not produce obvious effect on the pathogenesis of PCOS or contribute to insulin resistance, but OP may play a role in insulin resistance in PCOS patients.
