Study on the oral bio-availability of artemisinin solid dispersion system using Eudragit 100 as a carrier
- Author:
Hoa Dang Nguyen
- Publication Type:Journal Article
- Keywords:
artemisinine
- MeSH:
Artemisinine;
Pharmaceutical Preparations;
therapeutics
- From:Pharmaceutical Journal
1999;282(10):17-20
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
The oral Bio-availability of two different capsule formulations of artmisinin was carried out in six rabbits divided in two groups and seven healthy male volunteers in a single-dose crossover design with randomization for dosing sequence. The experimental results showed that the relative bioavailability of the formulation, that was made of artemisinin solid dispersion system using Eudragit L100 as a carrier on ratio 1:1, was more two times higher than the modification of artemisinin capsules without any modifications. There was a good correlation between in vitro dissolution data obtained by dissolution test with the mean AUG values of each studied group after oral administration.
