Association between single nucleotide polymorphism locus rs189037 in the promoter of ATM gene and nasopharyngeal carcinoma susceptibility in Cantonese.
- Author:
Hong-mei WANG
1
;
Yu-sheng SHI
;
Qi-sheng LI
;
Ying LIU
;
Xiao-kang ZHENG
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Asian Continental Ancestry Group; genetics; Ataxia Telangiectasia Mutated Proteins; Base Sequence; Carcinoma; genetics; Case-Control Studies; Cell Cycle Proteins; genetics; DNA-Binding Proteins; genetics; Female; Genetic Predisposition to Disease; Genotype; Humans; Male; Middle Aged; Molecular Sequence Data; Nasopharyngeal Neoplasms; genetics; Polymorphism, Single Nucleotide; Promoter Regions, Genetic; Protein-Serine-Threonine Kinases; genetics; Tumor Suppressor Proteins; genetics
- From: Journal of Southern Medical University 2011;31(11):1863-1866
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo evaluate the correlation between single nucleotide polymorphisms (SNP) in the promoter of ataxia-telangiectasia mutated (ATM) gene and the susceptibility of nasopharyngeal carcinoma in Cantonese.
METHODSA total of 176 NPC Cantonese NPC patients and 202 age-matched healthy controls were enrolled in this study. G/A genotyping of the SNP locus rs189037 in the promoter of ATM gene was performed by PCR and direct sequencing of the PCR products.
RESULTSThe genotype frequency of heterozygote G/A was 50% (88/176) and 47.5% (96/202), and that of the homozygote variant A/A was 15.3% (27/176) and 18.3% (37/202) in NPC patients and healthy individuals, respectively. Statistics analysis revealed no evident correlations of the G/A and A/A genotypes to the clinical phenotypes of NPC in either NPC group or healthy control group (OR7equals;1.022, 95%CIequals;0.668-1.564 for G/A+A/A). Analysis after stratification by age and gender found no such correlations either.
CONCLUSIONThe genotype frequencies of SNP locus rs189037 in the promoter of ATM gene are similar between NPC patients and healthy subjects, suggesting that rs189037 is not related to the genetic susceptibility of NPC in Cantonese.
