Effect of corticosterone on the delayed rectified potassium currents of cultured rat hippocampal neurons in vitro.
- Author:
Jing WANG
1
;
Qiang MA
;
Hong-Tao LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Animals, Newborn; Cells, Cultured; Corticosterone; pharmacology; Delayed Rectifier Potassium Channels; drug effects; Hippocampus; cytology; drug effects; Neurons; drug effects; physiology; Patch-Clamp Techniques; Rats; Rats, Wistar
- From: Chinese Journal of Applied Physiology 2003;19(3):253-255
- CountryChina
- Language:Chinese
-
Abstract:
AIMThe effect of stress hormone corticosterone on hippocampal neurons delayed rectified potassium currents was probed.
METHODSThe potassium currents of rat hippocampal neurons in primary culture were measured with patch clamp whole-cell recording.
RESULTSIt showed that the amplitudes of the potassium currents in hippocampal neurons decreased. However, the threshold potential of potassium currents increased.
CONCLUSIONIt is speculated that excessive corticosterone may hurt the hippocampal neurons via its effects on the potassium currents of rat hippocampal cells.
