Experimental study on the effect of ginkgo bioba extract on the expression of heme oxygenase-1 in bronchial asthma.
- Author:
Jin-Rong ZENG
1
;
Chang-Ming WANG
;
Yan ZENG
;
Bi-Wen MO
;
Hui HUANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Asthma; drug therapy; metabolism; Ginkgo biloba; Guinea Pigs; Heme Oxygenase-1; metabolism; Phytotherapy; Plant Extracts; pharmacology
- From: Chinese Journal of Applied Physiology 2003;19(3):302-305
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo explore the effect of the ginkgo bioba extract on the expression of heme oxygenase-1 (HO-1) in bronchial asthma.
METHODS30 guinea pigs were randomly divided into 3 groups (n = 10): (1) Normal control group; (2) Asthmatic group; (3) Therapeutic group. Blood carbon monoxide Hb (COHb) percent value, Airway resistance and eosinophilic inflammation of airway wall were observed, the expression of HO-1 in lung tissue were observed by immunohistochemical staining.
RESULTSThe expression of HO-1 was mainly located in airway epithelium in these 3 groups, the optical densities were 0.170 +/- 0.020, 0.707 +/- 0.058, 0.397 +/- 0.034, respectively. The asthmatic group showed higher optical densities than that of the normal control group (P < 0.01), and the therapeutic group showed lower optical density than asthmatic group (P < 0.01).
CONCLUSIONThe expression of HO-1 is inhibited significantly by the treatment of the ginkgo bioba extract, which may be one of the mechanism for treating asthma by ginkgo bioba extract.
