Effect of aspirin on pulmonary hypertension in rat during chronic hypoxia and hypercapnia.
- Author:
Hai-Huan ZENG
1
;
Liang-Xing WANG
;
Shao-Xian CHEN
;
Ming-Shan WANG
;
Xiao-Fang FAN
Author Information
- Publication Type:Journal Article
- MeSH: 6-Ketoprostaglandin F1 alpha; metabolism; Animals; Aspirin; pharmacology; Carotid Arteries; pathology; physiopathology; Epoprostenol; metabolism; Hypercapnia; physiopathology; Hypertension, Pulmonary; metabolism; pathology; physiopathology; Hypoxia; physiopathology; Male; Pulmonary Artery; pathology; physiopathology; Rats; Rats, Sprague-Dawley; Thromboxane A2; metabolism
- From: Chinese Journal of Applied Physiology 2003;19(4):319-322
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo study the effect of aspirin on chronic hypoxia and hypercapnic pulmonary hypertension.
METHODSSD rats were randomly divided into normal control group (A), hypoxic hypercapnic group (B), hypoxic hypercapnia + aspirin group (C). The concentration of TXB2 and 6-keto-PGF1alpha in plasma and in lung were detected by the technique of radioimmunology.
RESULTS(1) mPAP was significantly higher in B group than those of A and C group. Differences of mCAP were not significant in three groups. (2) Light microscopy showed that WA/TA (vessel wall area/total area) and PAMT (the thickness of medial smooth cell layer) were significantly higher in B group than those of A and C group. (3) The concentration of TXB2 and 6-keto-PGF1alpha in plasma and lung as well as the ratio of TXB2/6-keto-PGF1alpha were significantly higher in rats of B group than those of A and C group.
CONCLUSIONAspirin may inhibit hypoxic hypercapnia pulmonary hypertension and pulmonary vessel remodeling.
