Effect of bradykinin on the sodium channel current in dorsal root ganglion neuron.
- Author:
Hui BI
1
;
Jian-Ming PEI
;
Miao-Zhang ZHU
;
San-Jue HU
Author Information
- Publication Type:Journal Article
- MeSH: Action Potentials; drug effects; Animals; Bradykinin; pharmacology; Ganglia, Spinal; drug effects; physiology; Membrane Potentials; drug effects; Neurons; physiology; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Sodium Channels; drug effects; physiology
- From: Chinese Journal of Applied Physiology 2003;19(4):337-340
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the effects of bradykinin on voltage-dependent sodium channel currents in rat dorsal root ganglion neurons (DRG).
METHODSWhole-cell patch clamp technique was used to determine sodium channel current.
RESULTSBradykinin at 0.01 - 10.0 micromol/L dose dependently increased the frequency of repetitive firing of DRG. Bradykinin at 0.01 - 10.0 micromol/L dose dependently enhanced the TTX-R sodium current, and had no effect on TTX-S sodium current.
CONCLUSIONMechanism underlying the inflammation induced by bradykinin is related to the TTX-R sodium channel.
