C-fos expression within PVN and NTS of the rat induced by gastric ischemia/reperfusion injury.
- Author:
Yong-Mei ZHANG
1
;
Jian-Fu ZHANG
;
You-Ting CHEN
;
Chang-Dong YAN
;
Xiu-Ping ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Gastric Mucosa; pathology; Male; Paraventricular Hypothalamic Nucleus; metabolism; Proto-Oncogene Proteins c-fos; metabolism; Rats; Rats, Sprague-Dawley; Reperfusion Injury; metabolism; Solitary Nucleus; metabolism; Stomach; blood supply
- From: Chinese Journal of Applied Physiology 2004;20(1):20-23
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the effect of paraventricular nucleus (PVN) stimulation and the c-fos expression within PVN and nucleus tractus solitarius (NTS) of the rat following gastric ischemia/reperfusion injury (GI/RI).
METHODSThe rat celiac artery was clamped for thirty minutes and reperfused for sixty minutes, using Fos immunohistochemical method (ABC method) examined the c-fos expression within PVN and NTS.
RESULTS(1) Both electrical and chemical stimulation of the PVN obviously attenuated the GI/ RI. (2) Bilateral electrolytic lesion of NTS could eliminate the protective effect of electrical stimulation of the PVN. (3) The Fos-like immunoreactive neurons were increased in bilateral PVN and NTS by GI/RI.
CONCLUSIONThe function of PVN and NTS could be affected by the GI/RI noxious stimulation. PVN, NTS were involved in the regulation of GI/RI.
