Relationship between lung injury induced by hemorrhagic shock/reperfusion and nitric oxide and beneficial effect of taurine.
- Author:
Fang HE
1
;
Zhi-Ping SUN
;
Feng-Mei DENG
;
Hua ZHONG
;
Cheng-Jing CHU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Lung; drug effects; metabolism; Lung Injury; etiology; prevention & control; Nitric Oxide; metabolism; Nitric Oxide Synthase; metabolism; Rabbits; Reperfusion Injury; complications; drug therapy; Shock, Hemorrhagic; complications; drug therapy; Superoxide Dismutase; metabolism; Taurine; pharmacology; therapeutic use
- From: Chinese Journal of Applied Physiology 2004;20(1):54-57
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo approach the relationship between lung injury induced by shock/reperfusion and nitric oxide as well as the beneficial effect of taurine.
METHODSTwenty four rabbits were divided randomly into 3 groups (n = 8): control group, shock group, taurine group. The model of lung injury induced by shock/reperfusion was used. The activities of nitric oxide synthase (NOS), superoxide dismutase (SOD), the contents of malondialdehyde (MDA), nitric oxide products (NO2-/NO3-) in plasma and lung homogenate, lung wet/dry weight, lung water content, lung permeability index, and protein content in the pulmonary alveolar lavage fluid were measured. Meanwhile, pathologic samples treated routinely.
RESULTS(1) At 3 hours after reperfusion, the activities of SOD in plasma and lung homogenate decreased markedly, but the other indexes above mentioned were increased significantly compared with the control group (P < 0.01). (2) A close correlation was shown between MDA content and NO2-/NO3- content in plasma and lung. Furthermore, the content of NO2-/NQ3- in lung homogenate showed strong positive correlation with the lung injury parameters. (3) Taurine (40 mg x kg(-1) i.v.) could attenuate all the changes above mentioned at the same time points of reperfusion.
CONCLUSIONNO may play an important role in lung injury induced by shock/reperfusion. Taurine can ameliorate the lung injury, mechanism of which may be related to decreasing the generation of NO and anti-lipoperoxidation.
