Effects of exogenous testosterone on bone mineral density (BMD) and plasma levels of sex hormone and calcium, phosphorus in orchiectomized rabbits.
- Author:
Qiang WU
1
;
Xiao-Ying LI
;
Yan WANG
;
Hong ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Bone Density; drug effects; Calcium; blood; Male; Orchiectomy; Phosphorus; blood; Rabbits; Testosterone; pharmacology
- From: Chinese Journal of Applied Physiology 2004;20(1):75-77
- CountryChina
- Language:Chinese
-
Abstract:
AIMTo investigate the effects of testosterone on bone mineral density (BMD), plasma levels of sex hormone and calcium, phosphorus, and parathyroid hormone (PTH).
METHODSThirty 10 week old male rabbits were randomized into sham operated (SH), orchiectomized (ORX) and testosterone undecanoate replacement (TU) group. TU rabbits were injected with testosterone undecanoate in 10 orchiectomized rabbits and the remaining SH and ORX rabbits, vehicle only 20 weeks after initiation of the experiment, bone mineral density was measured with dual-energy X-ray bone densitometer. Blood was collected for determination of serum levels of total testosterone, estradiol, calcium, magnesium, phosphorus and alkaline phosphatase (AKP).
RESULTSThe serum levels of total testosterone and femoral neck BMD decreased, serum levels of calcium, magnesium and AKP increased significantly in ORX rabbits, testosterone improved femoral neck BMD and decreased serum levels of calcium, magnesium and AKP significantly in TU rabbits.
CONCLUSIONThe results of the present study indicate that ORX decrease serum testosterone and BMD, exogenous testosterone treatment can prevent osteoporosis in ORX rabbits.
